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DepartmentHaematology
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Emailfaridjohan [AT] usm [DOT] my
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Phone No6200
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Area of Expertise
- Molecular Haematology
- Molecular & Genetic Medicine
- Cancer Genetics & Epigenetics
Personal Information
Academic Qualification
|
Graduated Year |
Academic Qualification |
Place of Training |
| 2008 | PhD | University of Sheffield, United Kingdom |
| 2003 | MSc | University of Sheffield, United Kingdom |
Working Experience
|
Year |
Working Experience |
Place of Working |
| 2016-until now | Associate Professor DS54 | School of Medical Sciences, USM |
| 2008-2016 | University Lecturer DS51 | School of Medical Sciences, USM |
| 2008-2008 | University Lecturer DS45 | School of Medical Sciences, USM |
Awards
|
Year |
Award |
| 2010 | Berend Houwen Travel Award for attending the International Society for Laboratory Hematology (ISLH2010) in Brighton, United Kingdom |
| 2008 | Travel award from the Haematology Society of Australia and New Zealand (HSANZ) for the Annual Scientific Meeting HAA2008, Perth, Australia |
| 2004 | Travel and training fellowship from the Elimination of Leukaemia Fund (ELF) for the 46th ASH annual meeting & exposition, American Society of Haematology, San Diego, USA |
Research
|
Year Duration |
Research Title |
Grant Resource |
| Jan. 2019 – Sept. 2022 |
Elucidating the role of DNA methylation as modifiers of beta-globin gene in HbE/β Thalassaemia via an in-vitro model of epigenetic expression system, Associate Professor Dr Muhammad Farid Johan (PI), Co: Professor Dr. Shaharum Shamsuddin, Associate Professor Dr Abdul Aziz Mohamed Yusoff, Associate Professor Dr Ridhwan Abdul Wahab (UIAM), Professor Dr Wan Zaidah Abdullah, Associate Professor Dr Rosnah Bahar, RM180,800.00 |
Kementerian Pendidikan Malaysia (FRGS) |
| Nov. 2017 – Jan. 2021 |
The Development of Novel Baculovirus Insecticide Expressing Multiple Insecticidal Protein from The Natural Enemies of Red Palm Weevil (Rhynchophorus ferrugineus) Associate Professor Dr Muhammad Farid Johan (PI), Co: Profesor Dr Shaharum Shamsuddin, Puan Salmah Mohamed (UniSZA), RM93,106.00 |
Universiti Sains Malaysia (RUi-Research University Grant) |
| Mar. 2016-Aug. 2019 |
Identification of Genetic Aberration in Normal Cytogenetic AML and Correlation with Clinico Biological Parameters Head: Dr Marini Ramli, Co-Researchers (6): Dr Muhammad Farid Johan RM 178,000.00 |
Universiti Sains Malaysia (RUi-Research University Grant) |
| Mar. 2019-May 2021 |
Understanding the Apoptotic Effects of Epigenetic Modification Drugs on Proteome Profiles of Myeloid and Lymphoid Cell Lines Head: Faezahtul Arbaeyah Binti Hussain, Co-Researchers (3): Muhammad Farid Bin Johan, RM80,000.00 |
Universiti Sains Malaysia (RUi-Research University Grant) |
| Nov. 2020-Oct. 2023 |
The Role of Thalassemic Red Cell in the Mechanism Process of Hypercoagulable State in Thalassemia Intermedia and Major Patient Head: Rosnah Bahar, Co-Researchers (7): Muhammad Farid Bin Johan, RM42,000.00 |
Universiti Sains Malaysia (RUi-Research University Grant) |
| Jan. 2018 – Jan. 2019 |
Elucidating The Role Of TUBB2A, CCNA1 and SOCS3 Down-Regulation In Acute Myeloid Leukemia (AML) Cell Lines Treated With DNA Methyltransferase And Histone Deacetylase Inhibitors, Associate Professor Dr Muhammad Farid Johan (PI), Co: Siti Asmaa Mat Jusoh, RM10,000.00 |
Universiti Sains Malaysia (Bridging Grant), |
| Apr. 2016-March 2019 |
The Effects of NPM1, FLT3 and CEBPA Gene Mutations in Adult Patients with Acute Myeloid Leukaemia (AML) Head: Dr. Abdul Rahim Hussein, Co-Researchers (7): Assoc. Prof. Dr. Muhammad Farid Johan, RM 40,434.20 |
Universiti Sains Malaysia (Short Term Grant) |
| Aug. 2014-Dec. 2016 |
The mechanism of action of the negative regulators of JAK/STAT signalling pathway in resistant FLT3-ITD acute myeloid leukaemia cells Dr Muhammad Farid Johan (PI), Co: Prof Madya Dr Shaharum Shamsuddin, Dr Ridhwan Abdul Wahab (UIAM), RM 124,526.00 |
Kementerian Pendidikan Malaysia (FRGS) |
| Dec. 2011-Nov. 2015 |
Identification of Differentially Expressed Genes & Epigenetic Inactivation Profiling of Various Cytogenetic Rearragements in Primary AML Cell Lines Dr Muhammad Farid Johan (PI), Prof Madya Dr Shaharum Shamsuddin, Dr Abdul Rahim Hussein, Prof Madya Dr Rosline Hassan, Dr Badrul Hisyam Yahaya, Dr Azlan Husin, RM 240,662.25 |
Universiti Sains Malaysia (RU-Research University Grant) |
| Jan. 2012-July 2014 |
The Association of Genetic Alterations in FLT3, KIT and NRAS Genes with Treatment Response in Acute Myeloid Leukaemia (AML) Patients Dr Muhammad Farid Johan (PI), Prof Madya Dr Rosline Hassan, RM37,938.00 |
Universiti Sains Malaysia (Short Term Grant) |
| Aug 2016-June 2018 |
Understanding of anti-cancer properties of Neolamarckia cadamba leaves on breast cancer: Prospective therapeutic neolamarckia cadamba extracts Head: Assoc. Prof Dr Alfi Khatib (UIA), Co-Researchers (6): Dr Muhammad Farid Johan RM52000 |
Kementerian Pendidikan Malaysia (FRGS) |
| Aug 2016-Jan 2018 |
Understanding anti-angiogenesis mechanism of Porcupine Bezoar Bioactive Compounds On Colon and Pancreas Cancer Cells Using Xenograft Zebrafish Model Head: Dr Ridhwan Abdul Wahab (UIA), Co-Researchers (7): Dr Muhammad Farid Johan RM100,000 |
Kementerian Pendidikan Malaysia (FRGS) |
| Feb. 2013-Jan. 2016 |
Targeted Genetic Modifiers And Socio-Environmental Influences Contributing To Phenotypic Heterogeneity Of Hb E/ B Thalassemia Prof Zilfalil Alwi, Co-Researchers (35): Dr Muhammad Farid Johan RM 867,150.00 |
Universiti Sains Malaysia (RUT-Research University Team Grant) |
| Sept. 2014-Feb. 2016 |
USM-My-HVP-Sengenics Sdn Bhd Laboratory Head: Prof Zilfalil Alwi, Co-Researchers (15): Dr Muhammad Farid Johan RM 350,000.00 |
(RU Top-Down) |
| Mar. 2012-Aug. 2016 |
Genome-Wide Analysis for Genomic Alteration in Acute Promyelocytic Leukaemia Head: Prof Dr Rosline Hassan, Co-Researchers (4): Dr Muhammad Farid Johan, RM 231.600.25 |
(RUi-Research University Individual Grant) |
| May 2011-May 2015 |
Determination of Hypermethylation Status in Tumour Suppressor Genes (p16INK4a and p15INK4b) and 2 New Candidate Genes (PCDHGB7 and ADAM12) Among Chronic Lymphocytic Leukemia (CLL) Patients and Normal Individuals Head: Dr Sarina Sulong, Co-Researchers (5): Dr Muhammad Farid Johan, Prof Madya Dr Rosline Hassan, Dr Azlan Husin, RM 36,895.00 |
Universiti Sains Malaysia (Short Term Grant) |
| Dec. 2013-Nov. 2015 |
Understanding the Anti-Protiferative Mechanisms of Malaysian porcupine Bezoar on Breast, colon, prostate and tongue cancer cell Lines Head: Dr Ridhwan Abdul Wahab, Co-Researchers (4): Dr Muhammad Farid Johan, RM 81,000.00 |
Kementerian Pendidikan Malaysia (FRGS) |
| Nov. 2012-Aug. 2015 |
USM As Anchor for The Malaysian Node of Human Variome Project Head: Prof Dr Zilfalil Alwi, Co-Researchers (17): Dr Muhammad Farid Johan, RM 1,442,996.88 |
Universiti Sains Malaysia (APEX University Grant) |
| Mac. 2010-Mac. 2012 |
In Vitro Study of Mechanism of Resistance to Tyrosine Kinase Inhibitors in Leukaemia: Effects on Methylation in JAK/STAT signalling pathway Dr Muhammad Farid Johan (PI), Prof Madya Dr Rosline Hassan, RM 40,000.00, Mac. 2010-Mac. 2012 |
Universiti Sains Malaysia (Short Term Grant) |
| Dec. 2009-Dec. 2011 |
Effects of Malaysian Red Edible Plants as Anti-cancer Therapy of Signalling Pathway in leukaemic cell lines, Dr Muhammad Farid Johan (PI), Prof Madya Dr Rosline Hassan, Dr Azman Seeni, RM 50,000.00 |
Kementerian Pengajian Tinggi (FRGS) |
| Nov. 2008–Oct. 2009 |
Mutational screening of FLT3 and RAS genes in leukaemic cell lines using conformational sensitive gel electrophoresis (CSGE) Dr Muhammad Farid Johan (PI), RM 5,000.00 |
Universiti Sains Malaysia (Incentive Grant) |
Publication
Supervision
RESEARCH SUPERVISION
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Topic (Dissertation / Thesis topic) |
Level (PhD / MSc / Mixed Mode / Course work / Pro Course) |
Status (On-going / graduated status) |
Year (By year) |
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Investigation of the relationship between GATA3 transcriptional factor and C-MYC pro-oncogene in Peripheral T-cell Lymphomas (PTCLs) Mutaz Jamal Abed Al-Khreisat |
PhD | On-going |
Registered Oct. 2020 |
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Targeting Inhibitors of Histone Deacetylase and PI3K/AKT/mTOR Signaling Pathway in Sustained Minimal Residual Disease (MRD) Negative Multiple Myeloma Nor Hayati Ismail |
PhD | On-going |
Registered Sept. 2020 |
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Elucidating the role of DNA methylation as modifiers of beta-globin gene in HbE/Beta Thalassaemia via an in-vitro model of epigenetic system Nur Atikah Zakaria |
PhD | On-going |
Registered Oct. 2019 |
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The Development of Recombinnat Baculovirus Insecticides from the Natural Enemies of Red Palm Weevil as an Alternative to Cancer Causing Organophosphate Compounds Muhammad Azharuddin Azali |
PhD | On-going |
Registered Jan. 2018 |
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Genetic Risk Factors of Immune Thrombocytopenic Purpura Patients in Malaysia Muhamad Aidil Zahidin (Co-Supervision) |
PhD | On-going |
Registered Feb. 2020 |
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Gene mutational analysis of toll-like receptor (TLR) signalling proteins MYD88, IL-10, SOCS3, TNF-α and SHIP1 in myeloproliferative neoplasm Chia Yuh Cai (Co-Supervision) |
MSc | On-going |
Registered Sept. 2019 |
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The Effects of NPM1, FLT3 and CEBPA Gene Mutations in Adult Patients with Acute Myeloid Leukaemia (AML) Izaz Ul Haq (Co-Supervision) |
MSc | Graduated | 2020 |
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The Effects of Trichostatin A and 5-Azacytidine on the Differentially Expressed Genes and Epigenetic Profiling in Acute Myeloid Leukemia Siti Asmaa Mat Jusoh |
PhD | Graduated | 2019 |
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The mechanism of resistance to CEP701 in FLT3-ITD positive acute myloid leukemia (AML) Aziee Sudin |
MSc | Graduated | 2019 |
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DNA Methylation of LARP2 and IGSF4 as Epigenetic Modifiers in Transfusion Dependant Thalassemia Patients Haiyuni Mohd Yassim |
MSc | Graduated | 2019 |
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Genetic analysis of beta globin gene (HBB) and gama globin gene (HBG2) in HbE/B-Thalassemia patients Saripah Hanafi (Co-Supervision) |
MSc | Graduated | 2017 |
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The Role of FLT3 and NPM1 Genes Mutation in The Pathogenesis of Acute Myeloid Leukaemia Noraini Mat Yunus |
MSc | Graduated | 2015 |
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In Vitro Study of The Mechanism of Resistance to Tyrosine Kinase Inhibitors in The Pathogenesis of Myeloid Leukaemia. Hamid Ali Nagi Al-Jamal |
PhD | Graduated | 2015 |
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Cytotoxic Effects, S-Phase Cell Cycle Arrest and Apoptosis Induction of Aloe Emodin on Human Glioblastoma Multiforme U-87 MG Cells Samhani Ismail (Co-Supervision) |
MSc | Graduated | 2014 |
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The Effects of Trichostatin A and 5-Azacytidine on the Differentially Expressed Genes and Epigenetic Profiling in Acute Myeloid Leukaemia Siti Asmaa Mat Jusoh |
MSc |
Graduated |
2014 |
CLINICAL / ACADEMIC / LAB SUPERVISION
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Topic (Speciality / Field) |
Level (Pro Course / MMed / Fellowship) |
Status (Completed - Number of students supervised) |
Year (By year) |
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Characteristic and its association with driver gene mutations (JAK-2, CALR, MPL) In Myeloproliferative Neoplasm Dr Razan Hayati Zulkeflee (Co-Supervision) |
MPath | On-going | June 2019 - |
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Clinico-hematological profiling of Transfusion Dependent and Non-Transfusion Dependent among Beta Thalassemia Syndrome in Kedah Dr Fahmaa Azizi |
MPath | Completed | 2020 |
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Non-deletional alpha thalassaemia among screened population at Hospital Tengku Ampuan Rahimah, Klang, Selangor Dr Vasuhi a/p Kalimuthu |
MPath | Completed | |
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The effect of time duration and temperature on FBC parameters Subashini Arunasalam |
MPath | Completed | 2019 |
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Detection of leukaemia associated immunophenotype (LAIPs) in acute leukaemia and its association with haematological parameters and treatment outcome Dr Noor Shaidatul Akmal binti Ab. Rahman |
MPath | Completed | 2017 |
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Evaluation study of Nucleic Acid Testing (NAT) as a tool for blood screening at Unit Perubatan Transfusi (UPT), Hospital USM Dr Saif Ghazi Yasin Al-Qaisi |
MPath | Completed | 2011 |
UNDERGRADUATE SUPERVISION
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Topic (Speciality / Field) |
Level (Pro Course / MMed / Fellowship) |
Status (Completed - Number of students supervised) |
Year (By year) |
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Mutational analysis of the CALR gene in BCR-ABL-negative myeloproliferative neoplasms (MPN) patients at Hospital Universiti Sains Malaysia Nur Atikah Zakaria (Biomedicine, PPSK) |
PPSK | Completed | 2018 |
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Mutational screening of DNMT3A gene in Acute Myeloid Leukemia (AML) in Hospital USM Sarah Elyana Khairuddin (Biomedicine, PPSK) |
PPSK | Completed | 2017 |
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Mutational Screening of IDH1 gene in Acute Myeloid Leukemia (AML) patients at Hospital USM Nurul Amalina Mohd Nordin (Biomedicine, PPSK) |
PPSK | Completed | 2017 |
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Potential anti proliferative properties of methanol and water extracts of Pyrrosia Piloselloides on human cervical carcinoma cell lines, HeLa Fashihah Zakaria (Biomedicine, PPSK) |
PPSK | Completed | 2016 |
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In-vitro anti proliferative effects of Dendrophthoe Pentandra on Imatinib resistant BCR-ABL positive Chronic Myeloid Leukaemia Afiqah Zamani (Biomedicine, PPSK) |
PPSK | Completed | 2014 |
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The Inhibitory Effect of Physalis Minima Ethanol Extract on MV4-11 cell Farah Diziyana Mohd Zain (MD, PPSP) |
PPSP | Completed | 2012 |
Industrial Training
1. Amira Raudhah Abdullah (Biomedicine, PPSK), 2012, AML primary cell culture.
2. Mohamad Darwish Abd Aziz (Biomedical Sciences, UIA), 2013, Mutational Screening of c-KIT Exon 8 Gene in Acute Myeloid Leukemia.
3. Nur Izzati Mohamad (Biomedical Sciences, UIA), 2013, Mutational Screening of c-KIT 8 Gene in Acute Myeloid Leukemia.
4. Habibah Hassan (Biomedical Sciences, UIA), 2013, Mutational screening of KIT gene in Acute Myeloid Leukemia (AML).
5. Muhammad Azihan Ahmad (Biomedical Sciences, UIA), 2013, CSGE as method for mutational screening in KIT gene.